What to Know About the Calprotectin Stool Test

What do calprotectin stool test results mean?

High levels of calprotectin in stool may signal IBD, colorectal cancer, or infection.

What to Know About the Calprotectin Stool Test

Moderate or low levels mean there’s little to no inflammation present in the intestines. This may indicate that your symptoms are caused by a viral infection or IBS.

Calprotectin levels are measured within a reference range of numerical values indicated as μg/g (microgram/gram). According to the University of Iowa Dept. of Pathology Laboratory Services Handbook, the reference range for the calprotectin stool test is:

Normal (low, no inflammation)Moderate (borderline elevated)High
49 μg/g or less50–120 μg/g121 μg/g or greater

Normal (low, no inflammation) results. If your levels are low, your doctor may recommend self-care measures, like dietary changes, relaxation, and exercise for symptom relief. Antidiarrheal and antispasmodic medications may also be given.

Moderate (borderline elevated) results. If your levels are borderline elevated, your doctor may recommend retesting in several weeks, along with medication to alleviate symptoms. If bacterial infection is suspected, antibiotics may be given.

High results. If your levels are high, additional diagnostic tests, like a colonoscopy, will be done. This will help provide diagnostic information and determine the next steps for your care.